Chapter 3 Pathology Questions

Chapter 3 Review Questions 1. What is meant by the following terms Homologous chromosomes- A matched meet of chromosomes, unmatchable derived from each p arent. Both members of the pair are similar in size, shape, and appearance, except for sex chromosomes. Autosomes- The general term for chromosomes other than the sex chromosomes. conjure chromosome- The X and Y chromosomes that determine genetic sex. Barr organic structure- The inactivated X chromosome that appears as a sm whole, dense mass of chromatin attached to the nuclear membrane of incarnate cells.This structure flowerpot be identified in the cells of a typical female and is called a sex chromatin body or Barr body later on the man who first described it. Gene- Are segments of DNA duress that determine some property of the cell and are the basic units of inheritance. Sometimes, they are described as being pose along the chromosome like form on a string. Gametogenesis- A specialized type of cell office that occurs during the development of the eggs (ova) and sperm. The development of mature eggs and sperm from herald cells.Centrosome- A small region of cytoplasm adjacent to the nucleus that contains the centrioles and serves to orchestrate microtubules. 2. How does the process of mitosis compare with meiosis? In mitosis, each of the dickens bleak cells (called the daughter cells) resulting from the cell division receives the same number of chromosomes that were present in the precursor cell (called the call forth cell). In meiosis, the number of chromosomes is reduced so that the daughter cells receive hardly half of the chromosomes delivered by the parent cell. This process is non completed until fertilized by the sperm. . What are the differences between spermatogenesis and oogenesis? First, intravenous feeding spermatozoa are produced from each precursor cell in spermatogenesis, but only integrity ovum is formed from each precursor cell in oogenesis. The other three daughter cell s derived from the meiotic divisions are discarded as polar bodies. Second, spermatogenesis occurs continually and is carried through to complation in about 2 months. Consequently, germinal fluid always contains relatively fresh sperm. In contrast, the oocytes are not produced continually.All of the oocytes present in the ovary were formed before birth and have remained in a prolonged prophase of the first meiotic division from fetal feeling until they are ovulated. 4. What is a chromosome karyotype? How is it obtained? How is it used? A chromosome karyotype is an arrangement of chromosomes from a virtuoso cell arrangement in pairs in descending order harmonize to size of the chromosomes and the positions of the centromeres. A chromosome karyotype is obtained by culturing cells in a suitable medium. Usually, human race blood is used as a source of cells for these studies the blood lymphocytes washbowl be induced to undergo mitotic division.Certain chemicals are added to stop the mitotic division after the chromosomes have become separate and distinct, and consequently , many cells arrested in mitosis collect in the culture medium. Additional methods are employed to cause clod of the cells, which are then prepared, and the chromosomes can be examined. The chromosomes are then lay according to their size, the location of the centromere, the relative lengths of the chromatids that extend outward from the centromere, and the pattern of light source and dark bands along the chromosomes.Then the separated chromosome from one cell are photographed and arranged into a karyotype. The presence of abnormalities in chromosome number or structure can be detected this way. 5. What is the MHC? What is its function? What is its relationship to disease susceptibility? The MHC is the study histocompatibility complex. The antigens present on cells are determined by a clustering of genes on chromosome 6. This group of genes, which was first determined in laboratory anim als in connection with transplant experiments, is called the MHC.Originally, MHC proteins were considered of interest only with respect to organ transplantation because transplantation of cells containing MHC proteins different from those of the transplant recipient was followed by rejection of the transplant unless the immune system was suppressed. They take part in generating immune responses to foreign antigens of all types. The interaction of the HLA antigens with the various cells of the immune system is considered in the discussion on immunity, hypersensitivity, allergy, and autoimmune diseases. 6.What is a haplotype? How are haplotypes inherited by children from their parents? What are the chances that two children will have the same haplotype? A haplotype is a set of HLA genes on one chromosome and is familial as a unit. Each child receives one of two possible haplotypes from each parent. Because of the way in which chromosomes are transmitted from parent to child, the chi ld has any of four different combinations of HLA haplotypes. There is one in four probability that two children will both possess the same pair of HLA haplotypes.